The Inevitability of Suffering in James Baldwins Sonnys...

The Inevitability of Suffering in James Baldwins Sonnys Blues Everyone likes to feel safe. We try to protect ourselves and those we love, to make them feel safe as well. The idea conveyed about safety in James Baldwins Sonnys Blues is that there is no such thing. The narrator of this story had thought that his brother Sonny was safe. Or at least, that was what he had made himself believe. I told myself that Sonny was wild, but he wasnt crazy. And hed always been a good boy, he hadnt ever turned hard or evil or disrespectful, the way kids can, so quick, so quick, especially in Harlem. I didnt want to believe that Id ever see my brother going down, coming to nothing, all that light in his face gone out, in the condition†¦show more content†¦Thats when he started writing to his brother. My trouble made his real, he said (62). Because the truth is, we are never truly safe from anything. No one and nothing can protect us. This idea is brought out numerous times in the story. Driving past housing projects, where people have attempted to make nice, safe homes for themselves and their children in the midst of Harlem, and noticing the beat-looking grass and the big windows, and the playground, which saw more activity after dark, Sonnys brothe r notes: The hedges will never hold out the streets, and they know it (53). Sonnys brother is taking on the attitude he remembers hearing from their father. Safe! my father grunted, whenever Mama suggested trying to move to a neighbourhood which might be safer for children. Safe, hell! Aint no place safe for kids, nor nobody! (54). Sonny wasnt safe, no matter how much his brother had tried to protect him in his own way, by sending him to live with Isabel and her parents. He still got involved with drugs. The big brother syndrome kicks in again one day when Sonny had gone out. I was trying to remember everything Id heard about dope addiction and I couldnt help watching Sonny for signs. I wasnt doing it out of malice. I was trying to find out something about my brother. I was dying to hear him tell me he was safe (54). He was trying to protect his brother, but there was nothing heShow MoreRelatedExpectations in Sonnys Blues, by James Baldwin Essay1277 Words   |  6 Pagesthe Civil Rights Movement would gain momentum and drastically alter such social exclusion, but James Baldwin writes his story â€Å"Sonny’s Blues† before this transformation has occurred. In the style of other Post-Modernist writers of his day, Baldwin invents two brothers, Sonny and the narrator, who seem to have given up on find ing meaning in their lives: escape, not purpose, is the solution for suffering. Although marginalized by white society, these men are still influenced by external standards –

Factors Affecting Participation in Certain Sports Essay

Factors Affecting Participation in Certain Sports Your peers are the people you mix with who have similar interests and backgrounds and are roughly your age. Your peer group has a big influence on the way you behave and the things that you do. This is not always expressed words. If you wear the â€Å"wrong† clothes or do the â€Å"wrong† things you can very quickly feel left out. If you peers approve of an activity, you will feel encouraged to do it. Sadly, peer-group pressure can also force people to give up sports even though they enjoy them. Family Your family can have a similar effect on you as your friends can. We pick up many of our habits and†¦show more content†¦Socio-Economic The activity you participate in may be determined to a large extent by what you can afford. Activities like sailing, golf and riding can be very expensive so many people from lower socio-economic groups are excluded from them. There are also many activities that cost very little. A kick around in the park with a group of friends, for example, and sport at school are mostly free. Unemployed people are in a difficult situation: plenty of time to fill but not much money. To encourage them, sports facilities often charge less, especially at quiet times of the day. Age Young people are encouraged to participate at school and have plenty of free time to take up sport. It also depends on the activity. To be a good gymnast you need to be young and flexible. Today, however, with computer technology not all youngsters want to spend their free time playing sports and not all sports are open to very young people. People tend to take part less in physical recreation as they get older as they often have more responsibilities and less free time to spend on sport. Stereotyping can mean that older people are discouraged from being physically active. Some older people stereotype themselves and believe that they are too old to take part in physically activity. However, there are many sports that you can enjoy into your old age.Show MoreRelatedCorrelation Between Motivational Factors For Athletes And Athletes1328 Words   |  6 Pagesmotivational factors for athletes, and that there are also different attitudes or beliefs that athletes might have towards cert ain facets, such as doping or wanting to be successful. It is imperative that one understands that those same factors and or facets are quite similar if not identical to the factors and or facets associated with those athletes. Going forward, there will be an in depth examination of the correlation between motivational factors for athletes and those of sport ministries.Read MoreThe Effects of Social Factors in the Academic Performance of the Bbte Students College of Education1556 Words   |  7 PagesPOLYTECHNIC UNIVERSITY OF THE PHILIPPINES COLLEGE OF EDUCATION STA. MESA, MANILA THE EFFECT OF THE SOCIAL FACTORS ON THE ACADEMIC PERFORMANCE OF THE SELECTED STUDENTS IN THE BACHELOR IN BUSINESS TEACHER EDUCATION OF THE COLLEGE OF EDUCATION, POLYTECHNIC UNIVERSITY OF THE PHILIPPINES SBUMITTED BY: FLORENTINO, MARJORIE S. BENLOT, ZENNY T. FIESTADA, NATALIE JANE F. BBTE III-3D SUBMITTED TO: DR. CAROLINE SUMANDE I. INTRODUCTION In entering a new environment like universities and colleges, studentsRead MoreEssay on John J. Coakley on the Sociology of Sport1056 Words   |  5 Pagesothers in groups. The sociology of sport is seen as a subdivision of sociology where the main focus is on the relationship between society and sport. There are many ways to analyze the sociology of sport. One way is to look behind what society sees as real to see if things are really as they seem. Another way to analyze the sociology of sport is to objectively look at other views to gain another perspective. Also, a researcher could analyze the sociology of sport through a more scientific viewpointRead MoreThe Relationship Between Personality And Sports And Exercise1360 Words   |  6 PagesConsiderable amounts of research have been carried out on the relationship between personality and sport and exercise. A psychologist known as Eysenck introduced the Personality Theory in which he believed personality traits to have a â⠂¬Ëœbiological basis’ (Eysenck, H.J 1987). In addition, he also believed personality could be influenced by external factors such as the environment. Eysenck has indicated that there are, at least, three major dimensions of personality variation in the general human populationRead MoreViolence in Sports1840 Words   |  7 PagesLevel 3 PE Violence in Sport and its impact on NZ society Gaby Sansom In my report, I am going to be examining the role that violence plays in New Zealand sport and its impact on the New Zealand society. I will be addressing this topic from a rugby perspective therefore most of my examples will be rugby related. This is because rugby is one of the main sports in New Zealand to the extent that it has become an icon for us. No matter where youRead MoreAthletics In MacGregors Sporting Landscape Essay1940 Words   |  8 Pages As Macgregor’s athletics carnival lacks in the participation sector, with the research of Figueroa’s Framework mainly concentrating on the individual level has found that, with survey results shows that students feel that athletics is ‘uncool’ and would rather sit and chat with their friends. However, using tactics which corroborate teamwork and competitive factors which in theory will motivate students to strive and increase their participation levels. 1.0 Introduction This reportRead MoreIs Ajit A Better State Of Healthy Eating?1559 Words   |  7 Pagesoverview of this person’s current state of â€Å"Physical Activity†: Ajit, being an elite level athlete, performs an exquisite level of physical activity. He is extremely active, he engages in numerous training regiments and school sports as well. Besides his involvement in multiple sports at school he completes high intensity resistance training 2 hours a day for 6 days a week. A typical daily workout regimen of Ajit’s consist of: Warm Up/Dynamic Stretching: 10 mins Bench Press: 3-6 sets @ 6-12 reps BentRead MoreChildhood Obesity And Other Obesity Related Behaviors828 Words   |  4 Pagesactivity and other obesity-related behaviors. According to Paxson, Donahue, Oreleans, and Grisso (2006), over the past forty years, the built environment has changed dramatically affecting healthy behaviors and outcomes such as poor diet, physical inactivity, obesity and the disproportionate burden of these health risks among certain subpopulations (Rossen Pollack, 2012). Childhood Obesity in Los Angeles County Los Angeles County, the second largest city in the United States with a county populationRead MoreMaslow Hierarchy of Needs Essay1492 Words   |  6 Pagesfor example, counselling children in crisis (Harper, F. D., Harper, J. A., Stills, A. B., 2003). Maslow’s (1943) hierarchy is relevant to working with young people at school in many ways. One being that academic success is both an esteem need and a factor of self-actualisation, thus if schools want students to do well they must make sure that all their lower needs are met. For example, Steere (1988) suggests that if a child at school is hungry or thirsty, they will be unable to concentrate and learnRead MoreUniversity Services That Assist International Students1176 Words   |  5 Pagestaken an initiative by starting a program named English as a Second Language (ESL) specially for non native speakers of English. The students are made to attend classes which consist of lots of activities and learning. Students are provided with certain tasks as research papers where the student has to analyze and write on several issues. The students’ writing skills are assisted by Metro Writing Studio (MWS) which focuses mainly on the writing skills of the student. MWS helps the s tudents to focus

My Favorite Deserts Free Essays

ENGLISH COMP. 2. ASSIGN 2| A Description| | A description about my favorite desserts. We will write a custom essay sample on My Favorite Deserts or any similar topic only for you Order Now | | Mrs. Mirelle Jayawardene| 3/10/2013| | My Favorite Desserts Everybody has their favorite games, cars and meals. Also everyone has their desserts and I have mine. All my favorite desserts have one thing in common they all are made with one ingredient that is â€Å"Chocolate†. Mmm!! Chocolate Desserts! I honestly believe that chocolate is the closest we can get to heaven as mortals, seriously. Is there anything better than chocolate to make you feel all wonderful and gooey inside? Can anything cheer you up as instantly as chocolate desserts can? If you’re like me, you are going to love these Best Chocolate Desserts as well as the mouth-watering pictures of the amazing treats. So, what are we waiting for? Let’s dig in! Chocolate Decadence Cake Inspired by the old-school, ultra-rich, mousse like chocolate cake that usually called for a whole pound of chocolate, half a dozen eggs and lots of butter, here is an enlightened rendition with deep bittersweet chocolate flavor and that dense melt-in-your-mouth texture so characteristic of the genre. No one will guess it’s healthier. The secret is excellent natural cocoa powder and good-quality bittersweet chocolate, preferably with 70% cacao. Although the cake can be eaten once it’s completely cool, it comes out of the pan much easier and even tastes better if it has been chilled at least overnight. Frozen Chocolate-Covered Cappuccino Crunch Cake This cake is unbelievably awesome, delicious and easy to make and versatile; you can actually use other flavors to make it more appealing to those who are not coffee-lovers. Cappuccino Crunch Cake combines coffee ice cream, pound cake and NESTLE ® TOLL HOUSE ® Milk Chocolate Morsels for a rich and creamy frozen dessert! This dessert was created by Beth Royals of Richmond, VA. Simply Rich Chocolate Syrup This is not your average chocolate syrup, with its deep, rich and smooth chocolate flavor; the perfect treats for sweet fresh fruits, or to use for the topping of your favorite ice cream or dessert. Cinnamon Chocolate Pudding Chocolate and cinnamon has always been the perfect and a winning combination for any dessert. Cinnamon adds more warmth and deep scent to this special treat and this is one of the best flavors that a chocolate-lover can dream of because of its richness and creamy texture which is intensified by the whipped cream or any milk. Chocolate Banana Cream Pie The flavors complemented each other beautifully. The banana and chocolate -– a classic combo -– but brought to another level of interesting with the addition of the salted caramel, which also played nicely with the buttery graham cracker crumbs. Cool, creamy, sweet, and just so delicious. Chocolate Hazelnut Terrine with Raspberry Sauce This elegant dessert is a chocolate-lovers’ dream served in a pool of ruby-red raspberry sauce. Either made with hazelnut liquor, this will surely become a big hit because of its sweet taste. The good thing is you can make some changes. Instead of using heavy cream you can use whipped fat-free evaporated milk blended. For chocolate, you can substitute Dutch cocoa and cocoa white baking chocolate bar. Chocolate â€Å"Buried Treasure† Bars You will find sweet delight in every bite in this chocolate buried treasure bars, with layered almonds, dried berries and morsels; these bars are worth craving for. The combination of this bar will positively wow you’re lucky guests who have the golden opportunity to taste this fantastic chocolate treat. In all these wonderful pictures that have been displayed above lies a wonderful, mouth watering and breath taking taste that I have had the pleasure of indulging in. I have tasted these wonderful treats mainly when I was on vacation in different countries and different cities. There are many more wonderful delicious treats that I have not mentioned and the reason for that is, those delicious desserts had no real description, because I could not describe them. They are indescribable; there taste was so sweet and tender that my taste buds could not control themselves. I have been too many countries, seen many cities and tasted many desserts enough to know that the desserts I have mentioned above are for me the top 7 that I will always want to taste just one more time. Desserts are described as a sweet, delicious conclude to a wonderful meal that brings you to utter the words â€Å"Delicious†. My dreams vary from entertaining people, discovering and studying history and as of my last vacation that solidified my professional like taste buds; my new dream is to travel the world tasting all the delicious desserts. How to cite My Favorite Deserts, Essay examples

Brave New World Essay Research Paper Aldous free essay sample

Brave New World Essay, Research Paper Aldous Huxley # 8217 ; s Brave New World is a fabricated narrative about a hereafter Utopian society where people are mass-produced in research labs. Peoples have no emotions in this universe where drugs and promiscuous sex are greatly encouraged. Peoples are given labels harmonizing to their pre-natal intelligence assignment. These different categories all have specific functions within society and cipher is unhappy with their topographic point. The Brave New World he was a fabricated narrative that sets up a symbolic mirror to our universe that shows the reader what our universe is easy germinating to. As immature kids, the Utopians are conditioned to pattern certain rites, to subsequently profit society as a whole through the stableness that these patterns bring. One of the Acts of the Apostless that the kids are taught to make is get down to experiment sexually at a really immature age. This will forestall sexual anxiousness in their grownup old ages. Sexual drama is greatly encouraged to the point that a particular clip is set for kids to experience an titillating drama. # 8220 ; In the garden it was playtime. Naked in the warm June sunlight, six or seven hundred small male childs and misss were running # 8221 ; ( Huxley 30 ) . As they grow older, sexual promiscuousness becomes a demand among the grownups. In order for them to maintain a stable society, the Utopians can non put on the line strong emotions among its people, if it is allowed people will be preoccupied with emotion therefore taking to under production. The attitudes of the Utopians support thoughts of no monogamousness. As one character said, # 8220 ; You ought to be careful. It # 8217 ; s such dreadfully bad signifier to travel on and on like this with one adult male # 8221 ; ( Huxley 41 ) . Huxley commented on his narrative # 8217 ; s relevancy to the current clip ( Huxley # 8217 ; s book was published in 1932 ) , with regard to the sexual attitudes of the people of the Brave New World. He said, # 8220 ; Nor does the sexual promiscuousness of Brave New World seem so really distant. There are already certain American metropoliss in which the figure of divorces is equal to the figure of matrimonies # 8221 ; ( Huxley frontward ) . Huxley is stating that although our society would wish to believe that it is sexually stable, there is a deficiency of monogamousness among the general population. Another facet of the Brave New World civilization that is symbolically similar to our ain civilization, is the really distinguishable caste system. Peoples of the Brave New World are # 8220 ; born # 8221 ; with a specified intelligence degree. This degree of high quality ( or lower status ) is group into different castes. For illustration, Alphas are the smart superior persons, where as the Gammas are among the lower castes that are mass-produced to be about indistinguishable. This is their manner of sorting people harmonizing to each person # 8217 ; s biological make-up. Huxley remarks on the biological caste system in his forward, # 8220 ; the equivalents of # 8230 ; the scientific caste system [ of the Brave New World ] are likely non more than three or four coevalss away. † Looking at our society today, we can see many ways in which biological science determines personal worth. Many of today # 8217 ; s highest paying occupations travel to those of biological high quality. Biologically superior supermodels receive 1000000s of dollars because they were born with a pretty face. Athletes get regard and money for playing athleticss. Biology helps the football participant because it makes him fast. By giving them physical high quality, such as tallness, hoops and volleyball participants are assisted by biological science. Colleges and universities are discriminate against those who are biologically inferior because they merely allow people that are highly intelligent into their installations. Even though we haven # 8217 ; T begun doing people with a specified biological science, we are utilizing the biological science that a individual inherits to put them in, above, or below everyone else. Although Huxley doesn # 8217 ; t believe that we are close to making people in the research labs, as he said in portion of his forward, # 8220 ; technically and ideologically we are still a long manner from bottled babes, # 8221 ; nevertheless, Joseph Needham believes we are close to this # 8220 ; bottled babe # 8221 ; . In his 1932 reappraisal of Brave New World in # 8220 ; Scrutiny # 8221 ; , he wrote that, # 8220 ; successful experiments are even now being made in the cultivation of embryos of little mammals in vitro, and one of the most horrible of Mr. Huxley # 8217 ; s anticipations, the production of legion low-grade workers of exactly indistinguishable familial fundamental law from one egg, is absolutely possible. # 8221 ; Today there is important promotions being made everyday in the Fieldss of familial technology. We # 8217 ; ve cloned a sheep, how shortly before we clone worlds? Another really near to place rite among the people of this Utopia is the usage of drugs. The people of Brave New World use a drug called haoma to unclutter the head of everything bad and do themselves experience happy. In his forward, Huxley besides wrote about haoma. He said, # 8220 ; the equivalents of some # 8230 ; are likely non more than three or four coevalss away. # 8221 ; In current society there are many flights from world that allow a individual to be happy when they # 8217 ; re down, Prozac is merely one of many drugs with this intent. Prozac is advertised as something that can work out any and all mundane blues. Many people in the universe usage Prozac in order to do them happy and to take away their jobs, merely the same manner the people of Brave New World do with haoma. Through out this narrative, Huxley uses the patterns these people do as an illustration to demo modern twenty-four hours readers by mirroring what our society could go if we # 8217 ; re non careful. Huxley uses these comparings to demo that the Brave New World could go on. He writes about this besides in his forward, # 8220 ; All things considered it looks as though Utopia were far closer to us than anyone, merely 15 old ages ago, could hold imagined. # 8221 ; Bibliography Huxley, Aldous. Brave New World. New York: HarperCollins Publishers, 1932.

How The Rich Benefit From The Poor Essays (5454 words) -

How The Rich Benefit From The Poor How the Rich Benefit From the Poor The United States is the most developed capitalist economy in the world. The markets within the economy provide profit-motivated companies endless potential in the pursuance of pecuniary accumulation. Throughout the twentieth-century competitive companies have implemented modernized managerial procedures designed to raise profits by reducing unnecessary costs. These cost-saving procedures have had a substantial effect on society and particularly members of the working class. Managers and owners of these competitive and self-motivated companies have consistently worked throughout this century to exploit the most controllable component of the production process: the worker. The worker has been forced by the influence of powerful and affluent business owners to work in conditions hazardous to their well being in addition to preposterously menial compensation. It was the masterful manipulation of society and legislation through strategic objectives that the low-wage workers were coerced into this position of destitute. The strategies of the affluent fragment of society were conceived for the selfish purpose of monetary gain. The campaigns to augment the business position within the capitalist economy were designed to weaken organized labor, reduce corporate costs, gain legislative control and reduce international competition at the expense of the working class. The owners have gained and continue to gain considerable wealth from these strategies. To understand why the owners of the powerful companies operate in such a selfish manner, we must look at particular fundamentals of both capitalism and corporation strategy. Once these rudiments are understood, we will more clearly relate the perspective of the profit-seeking corporations of America. Legal discussion will also be included to show how the capital possessing elite operate through political parties to achieve their financial objectives. It is the synergist effect of these nu merous strategies that have lead to the widening income gap in America, persistent attempts of contraction in workers rights and increased corporate political influence. These campaigns have come at an expense to Americans and will only continue to benefit the affluent society. Creating Corporate Value The United States is a capitalist economy. In a capitalist economy individuals who wish to gain wealth can invest their capital into markets in hopes of future returns. If this investment gains in value then the investor has earned a return, which can be reinvested. This creates a cycle of investing and reinvesting for potential future return. This wealth creating cycle is a fairly simple concept to understand, but wealthy individuals have learned to fabricate this cycle into different situations. A common form of investment is purchasing and selling of corporate stocks. The stock market works like all markets on the fundamental theory of supply and demand. The more demand for a stock the higher it is valued and conversely the less demand the less it is valued. Corporations are legal entities which issue stock to investors who purchase them and become shareholders of the company. The risk taken by investors is that when they buy stocks it is possible that the individual company will not do well, or that stock prices will generally weaken. At worst, it is possible to lose entire investments, but no more then that. Therefor, shareholders of a corporation are not responsible for corporate debts. So, a corporation would be a very attractive type of investment for potential investors to consider. Corporations compete against each other in markets in the United States and around the world. These corporations have employees who perform various functions that contribute to successful strategic goal completion. Corporations often will offer stock incentive plans strategically to employees in positions of importance. The enticement to employees is to work in a manner that will increase the value of the company and their shares of stock. These incentive plans were strategically developed by major shareholders because the corporate executives felt that people would be motivated to increase their own wealth. Most employees are motivated by money and will work harder when the chance is given for more money. The very nature of this strategy consolidates all the employees to act as one self-motivated entity in the pursuit of monetary accumulation. In Piven and Clowards Regulating the Poor, this point is illustrated: Capitalism, however, relies primarily upon

Paper 5

Paper 5 Paper 5 Sarah Goodman Ms. Redden ENG W233-12 11 November 2014 Stress With College Students â€Å"How am I going to get all of this homework and studying done by Tuesday?† I said to my freshman-self as I sat at my cluttered desk on a Friday night after finishing a shift at work. I felt so inexperienced and immature. â€Å"I won’t always feel like this†¦Ã¢â‚¬  I thought while looking at five assignment sheets at once, â€Å"surely I will get used to this workload eventually.† Little did I know I would experience this same overwhelming feeling of stress that filled me in my first year of college, almost every day of my college career. The type of question I asked myself that night is one that I still often find myself asking throughout the span of each passing semester. Constant thoughts of assignments, exams, work schedules, countless deadlines, and not to mention, when I plan to sleep, fill my mind every minute of every day. I felt, and still frequently feel, so overpowered by negative emotions regarding all of the responsibilities that come with being a successful college student. I am not alone with these negative feelings toward stress. Among most college students that I know and have been in contact with, all say that they endur e tremendous amounts of stress that are related to their college careers. Most times, this stressful feeling that students experience is the result of factors such as, overcrowded schedules due to work and classes, as well as all of the work that must be completed in order to do well in college courses. For most college students, stress is something that is inevitable and is difficult to treat or overcome. Today, more and more students attend college universities and with this, arises a significant increase in stress among this generation of college attendees. With today’s college students being plunged into very intellectually and physically demanding courses, majors, and classroom atmospheres, stress has become a common idea that is associated with everyday college student life. When facing this ongoing stress almost everyday, students do not often realize the negative effects that can influence them mentally and physically. While students do not always consider these adverse consequences, they still exist, and have been researched widely by many concerned academics and specialists. The past research done on this topic has shown that stress and its negative effects are both increasing problems among college students and the means of treatment for stress are widespread and still significantly unused. Although research has touched on many elements of stress with college students, not all results stemming from the research is clear in answering certain questions. Can college students actually treat their stress? What are the best ways to treat stress for college students? Can college students turn stressful factors into positive ones? Do different demographics of people including gender, age, and race; have different ways of treating stress? In this generation of students, the issue of stress and its negative effects is relevant to everyone attending college and to the families and friends of those attending college. These unfavorable outcome s can considerably impact students’ overall health and wellbeing. It is important for everyone to be aware of the increasing problem of stress in college student lives and how the negative effects of it may impact their health. In order to actively support and improve the health and knowledge of college students, this issue must be considered. There are several key terms that will be used throughout this argument that have a specific meaning linked to the topic of stress. Stressors are closely related to the negative aspects of stress in that they are all of the people, things, and situations that cause one’s stress and the negative effects from it. Stressors can vary from things such as schoolwork, relationships, jobs, and pressure to do well. Coping

Dorothy Parker, The Waltz Research Paper Example | Topics and Well Written Essays - 1000 words

Dorothy Parker, The Waltz - Research Paper Example She reveals the reality of the treatment of women by men and shows how they were trapped in a male-dominated society during the twentieth century. It is an autobiographical account of her experience which involved sexism and how she conforms to the expectations of the society. The opening lines express the relationship between man and woman which is that of hatred yet there is a sense of dependence both inherent and induced through social pressure. In response to a simple question â€Å"would you like to dance?† a woman is often heard to reply in the affirmative. However the opening lines tell the reader that the female character is unwilling to do so. In fact her sentiments are so strong that it appears that she is completely frustrated with the cliched gestures that women show towards men as a weaker sex: â€Å"I don’t want to dance with him. I don’t want to dance with anybody. And even if I did, it wouldn’t be with him. He'd be well among the last ten. I've seen the way he dances. Just think, not a quarter of an hour ago, here I was sitting, feeling so sorry the poor girl he was dancing with. and now I'm going to be that poor girl.† (Parker 1942) As one reads on through the story he realizes that it is rather a satirical parody of women’s attitude towards men. ... The monologue, through which the entire story is narrated, is a true expression of the speaker which is not only outright but also comforting. The language used is very concrete and feminine. It not only parodies the feminine language but also the masculine aspect of it making it all the more interesting. The rhetorical question that the story poses is about the possible response a female can give to a man who is offering her to dance with him (Pettit 241). For Parker, being smart and cute were the only two available attitudes for her as a woman in the early twentieth century. This shows that the story has a quasi-autobiographical discourse. The way she incorporates the textual environment of the early 1930s is a remarkable achievement of the author who accepted and resisted using the language of popular literature in all her works. The complex parodic paradigm of the use of language in the short fiction is an aspect which drives more attention to the story than just its appearance i n a particular magazine in a particular time period (Bennett112). The question â€Å"would you like to dance?† is a unique speech act which lies somewhere between a command and a genuine question. The face value of this question is a freedom of choice for the women but it is the situation where she is asked that she is compelled to reply in affirmative even if she does not want to. She does have the freedom to decline but she is also elated by the fact that someone at least asked her. The story suggests that women find an agency through humor and the speech-act that it allows is a limited agency. Parker combines and represents the words of the women which allows for them to share the humor which leads to a

Quality Leadership and the Technology Manager Research Paper

Quality Leadership and the Technology Manager - Research Paper Example From the discussion it is clear that  technology Management refers to a class of management principles that permit organizations to have control of their technological essentials to dictate competitive power. Typical ideas exercised in technology control normally follow as technology plans – a sense or task of technology within an organization. The other ideas follow as technology forecasting. This refers to noting of probable appropriate technologies for an organization, possibly through technology inspection. The second idea follows as technology road mapping; this means mapping technologies to businesses plus market requirements. Technology project portfolio falls as the third idea; it refers to a set of projects under expansion.  This report  will explain in details the materials used in research. The research used seven sources to come up with its findings. Below follows a detailed review of the seven sources of the research material. Quality management: creating an d sustaining organizational effectiveness stands as the leading book in the research. The author named Donna Summers compares a business to a kaleidoscope. He says that destructing the nature of the patterns of a kaleidoscope mirrors will only form a new pattern. This links to a business in the logic that managers set patterns to bring achievement and if a destruction or failure occurs it means that new pattern is formed. The second book talks about the fundamental values of total quality and stress on high performing management practices. It gives examples of wealthy existing leading organizations throughout the globe. The writing portrays quality as it emphasizes the practical aspects of managerial focus and relevant technical topics. The book covers most of the knowledge needed for management certification. It stands as everything managements would require, at the present and throughout their operations, this will make sure quality management comes to succeed. The third writing, authored by Robert Emerson referrers to as Business Law; the book written in Barron's Business Review Series focuses on the significances of legal assumptions in the day to day business sector, referring to such topics as tort responsibility, government policy, contracts, ecological law, product accountability, consumer protection, and international law, among many other subjects. Also, discussed in details are the legal aspects of franchises, partnership and corporations, and exceptional topics that comprise of business misdemeanors, property as a lawful concept, rational property, plus similar, relevant topics. The book c

A comparative analysis of international business environment in china Essay

A comparative analysis of international business environment in china and russia to determine which of these countries is in better position to succeed in the new global economy - Essay Example In light of this, globalization refers to the progression towards unifying business interactions across the global platform as opposed to within a given country or organization’s locality. It is the framework upon which international business is structured, and is the direction that business transactions are taking in recent times. However, there are various conditions that define the international business environment, and as such, this affects the success rates of various nations in succeeding in the new global economy. To this end, a comparative evaluation between Russia and China can highlight their viability in the new global economy. As such, Russia stands a better chance of succeeding in the international business environment and being the future of the new global economy when analyzed against China. For a start, Russia’s foray into the international platform started with its rich history as highlighted by its supremacy during the cold war. The cold war was a period of military and power tussle between the countries of the eastern and western blocks after the end of the 2nd World War (Bellacqua 2010, p. 99). The Western Bloc was largely represented by the United States while the Eastern Bloc was represented by Russia, then known as the USSR, and its allies. The cold war was largely psychological and never developed into a full-blown war. However, by being part of it, Russia gained a lot of exposure and experience in worldly relations and overall familiarity with international participation in matters of both national and international interest (Levin 2008, p. 154). As such, this gives it a much needed head start in being a globalization and international business powerhouse, as it has better experience in international relations. In order to succeed in globalization, inte rnational relations is of particularly significant importance as international business involved relations between nations and regions in

Huge Inflammatory Myofibroblastic Tumor in Teenager

Huge Inflammatory Myofibroblastic Tumor in Teenager Abstract Background: Inflammatory myofibroblastic tumor (IMT) is a rare benign neoplasm. The huge IMT of chest is even rarely observed and there is few literatures described the disease. Case presentation: A 17-year-old girl who suffered from a dry cough with right chest pain. Contrast-enhanced CT showed a huge heterogeneous mass with calcified plaques. A surgical management strategy was successfully undertaken. Increasing physician awareness of this entity should facilitate recognition of its clinical characteristics and laboratory findings. Conclusions: This case suggests that a rarely huge and surgically treated IMT in a teenager and concerned with the radioclinical, histopathological, therapeutic aspects of this disease. Keywords Inflammatory myofibroblastic tumor, Lung, Surgery Background Inflammatory myofibroblastic tumor (IMT) is a rare benign tumor that often affects children. It has been first described by Brunn in 1939 [1] and it accounts for 0.71% of all lung tumors. [2, 3]. The origin of the IMT is unknown, but recent studies have shown that it is a true tumor rather than a reaction process [4]. Different terms used to describe IMT include inflammatory pseudotumor, cellular inflammatory pseudotumor, plasma cell granuloma and inflammatory fibrosarcoma. This lesion consists of inflammatory cells and myofibroblastic spindle cells [5, 6]. We report a case with a rarely huge and surgically treated IMT in a teenager and concerned with the radioclinical, histopathological, therapeutic aspects of this disease. Case presentation A 17-year-old girl was referred to our hospital with a 15 days history of right chest and cough without sputum. She denied the following symptoms including the presence ofhoarseness, hemoptysis, anddyspnea. Her medical history and family history were uneventful. Physical examination revealed normal breath sounds in both of the lung fields. The results of laboratory examinations, including arterial blood gases, hematology tests and biochemistry tests, were within normal limits. Her Pulmonary function tests and cardiovascular examination revealed normal performance. Contrast-enhanced chest computed tomography (CT) showed an 18Ãâ€"16Ãâ€"15 cm heterogeneous mass with calcified plaques invading the entire right hemithorax and mediastinal shift to the left (Fig 1A, 1B). However, the patient refused to have the bronchoscopic examination and fine-needle biopsy of the mass. As diagnosis was not established through imaging, surgery was scheduled. Under general anesthesia with selective intub ation, a huge mass (measuring 20Ãâ€"17Ãâ€"17 cm and weighing 2010g) with inferior vena cava and right pericardium invasion was found and the right middle and lower lobes bronchus appeared encased by the mass. At last, the neoplasm was completely excised. The patient underwent a right middle and lower lobectomy, inferior vena cava angioplasty and partial resection of pericardium. Mediastinal lymph node dissection was also accomplished. The feeding vessels of the mass were ligated and the mass was removed without tumor spillage or capsular injury. After that, reexpansion of the right upper lobe was observed and a chest tube was placed to drain the pleural cavity. A postoperative roentgenogram of the chest showed that the mediastinum had returned to its normal position and the right lung was well expanded. Microscopic examination revealed a proliferation of regular spindle cells arrayed in fascicles, admixed with lymphocytes, plasma cells and eosinophils. Additional immunohistochemis try with anaplastic lymphoma kinase (ALK)-1 and smooth muscle actin (SMA) revealed positive and the translocation of the ALK gene was found by fluorescence in situ hybridisation (FISH). The results for desmin, S-100, CD99, CD34, Myogenin, EMA and pankeratin were negative. Ki-67 proliferative activity was 8%. Based on these data, the diagnosis of inflammatory myofibroblastic tumor was retained. Histologic diagnosis showed a negative bronchial margin and lymph nodes free of malignancy. The patient made an uneventful postoperative recovery and was followed up for two months without evidence of recurrence to date. Conclusions Inflammatory myofibroblastic tumor (IMT) is a rare massforming lesion characterized by fibroblastic or myofibroblastic spindle cell proliferation with varying degrees of inflammatory cell infiltration. The World Health Organization (WHO) classified IMT as a distinct entity in 1994 [7]. However, the huge inflammatory myofibroblastic tumor of chest is even rarely observed and there is few literatures described the disease (Table). The cause of IMT tumors is unclear, but an immunological response to an infectious agent or noninfectious agent remains possible [8]. Whereas some reporters demonstrated that IMT tumors are true neoplasms and some believe the IMT tumors to be a low-grade sarcoma with inflammatory cells as it has a potential for local recurrence, infiltration, multicentricity, and rarely metastases [9]. Also, ALK positivity is detected in 36% to 60% of cases and the presence of chromosomal aberrations in these tumors suggests that IMT is a neoplastic proliferation of clonal or igin [10]. In our case, there was no evidence of infection or inflammatory response and no history of trauma in her chest. The tumor was single and circumscribed, and movable. The IMT affects both sexes, at any ages, with a slight predominance in children and young adults [4, 11]. Most patients are asymptomatic and the tumor is discovered incidentally on a chest X-ray performed for another reason [4, 11].From the table, all of the four patients were young adults and were referred to the hospital with a common symptom of cough. In our patient, the tumor was discovered at an early age and the only symptoms were dry cough and right chest pain. Radiological aspects are capricious. Chest radiographs are the most generally performed imaging study to evaluate the neoplasm. Most patients have a mass or a pulmonary nodule, generally measuring 1 to 6 cm in diameter [12]. On CT scans, these tumors shows typically heterogenous attenuating enhancement [6]. Sometimes the tumor can extend towards the hilum, mediastinum, pleura or diaphragm [1, 3]. As recorded in the table, all the sizes of masses were huge and two of them were observed the invasion of the mediastinal or the chest wall. There is also a word of caution in our case that the representative calcifications were observed in the centure of heterogeneous mass and it invaded the inferior vena cava and right pericardium. Microscopically the IMT tumor consists of spindle shaped cells that are mixed with a chronic inflammatory component that consists of plasma cells, lymphocytes, and occasional histiocytes. Immunohistochemistry for ALK discovered cytogenetic abnormalities on chromosome 2p23 is relatively specific for IMF tumor among the spectrum of fibroblastic-myofibroblastic tumors and other potential mesenchymal mimics of IMF tumor [13]. The recent WHO classification of soft tissue tumors recognizes 3 basic variants of IMT: (1) loosely organized myofibroblasts in an edematous myxoid background with plasma cells, lymphocytes, eosinophils, and blood vessels, resembling nodular fasciitis; (2) dense aggregates of spindle cells arrayed in a variable myxoid and collagenized background and admixed with a distinctive inflammatory infiltrate, diffuse clusters of plasma cells, and lymphoid nodules, resembling fibrous histiocytoma or fibromatosis; and (3) collagen sheets with scattered plasma cells and eosinop hils resembling a scar or desmoid tumor [14]. The differential diagnosis of IMT is follicular dendritic cell tumor and inflammatory pseudotumor. Follicular dendritic cell sarcoma (FDCS), which was first reported by Monda et al. in 1986, is a rare neoplastic proliferation that exhibits the morphological and immunophenotypic features of FDCS that are among the accessory cells of the lymphoid system. The tumor cells exhibited positive immunohistochemical staining for vimentin, CD21 and CD35 as well as negative staining for ALK-1 and SMA. Inflammatory pseudotumors are benign tumors commonly found in the lung and they are characterized by proliferation of spindle cells (fibroblasts and myoblasts), with variable numbers of mitoses, and inflammatory cells infiltration, particularly plasma cells. More recently, the presence of anaplastic lymphoma kinase (ALK 1) staining in some cases has been postulated to be of value in the confirmation of IMT and in its distinction from other entities. A series of studies found the translocation of th e ALK gene by fluorescence in situ hybridisation (FISH) in IMT (16). In our case, the mass was spindle cell lesion with severe atypism and some mitosis. As shown in Fig 2 (A, B, C), ganglion-like cells were present and the immunohistochemistry result for ALK-1 shows strong positivity of tumor cytoplasm and translocation of the ALK gene. Based on these findings, her tumor may be very aggressive. Despite IMT is a benign tumor, it is considered by some authors as a low grade tumor because of malignant features such as local invasiveness, recurrence or malignant transformation. Complete surgical resection is the appropriate treatment for IMT. Cerfolio and colleagues reported an excellent prognosis in patients undergoing complete resection of pulmonary IMT, with a 5-year survival rate of 91.3%. However, a 60% recurrence rate in those receiving incomplete resection has been reported in the same study [15]. Corticosteroid monotherapy may result in rapid resolution of the disease and sustained remission (17, 18). Non-steroidal anti-inflammatory agents (NSAIDs) as solitary therapy may be extremely efficacious and anecdotal response to chemotherapy has also been reported (19). As the literature reviewed in the table, three patients had the operations by a standard posterolateral thoracotomy. Among them, two patients had the lobectomy and the other had the complete resection with two through fourth ribs. The patient whose neoplasm invaded superior vena cava, heart atrium and right pulmonary vein underwent chemotherapy with bleomicin, etoposide and cisplatin. After two cycles of chemotherapy, the tumorslightly reduced in size and the patient only survived for 12 months. In summary, inflammatory myofibroblastic tumor is a rare benign tumor. Because of its local invasiveness and its tendency to recur, IMT tumor can be confused with malignant lesions. Because the treatment of IMT tumor is conservative surgery, preoperative recognition is important to avoid radiation therapy, and intensive multi-agent chemotherapy that would be appropriate treatments for soft tissue sarcomas. Clinical and radiological presentation is variable and nonspecific and the diagnosis is rarely made before chirurgical management. Also, because the tumor with cellular atypia, ganglion-like cells, ALK and SMA reactivity has a more aggressive clinical behavior, a careful follow-up is required. Figure legend Figure 1: CT features of the case. A and B: Contrast-enhanced CT showed a huge heterogeneous mass with calcified plaques. Figure 2: Histological and immunoistochemical features. A: Hematoxylin-eosin staining demonstrating spindle cells sprinkled, with a predominance of plasma cells and lymphocytes. (X400) B: Immunohistochemical staining showing strong reactivity for anaplastic lymphoma kinase (ALK)-1(X400) C: Immunohistochemical staining showing strong reactivity for smooth muscle actin (SMA) (X400) 1

Telecommunication :: essays research papers

Fuzzy Sets and Systems Lotfi A. Zadeh, The founder of fuzzy logic comp.ai.fuzzy New fuzzy archive by thread. Fuzzy Logic Tools and Companies. General sources of fuzzy information. Maintained by Bob John. Conferences and Workshops on Fuzzy Systems: 1990-2001 From the Parallel and Distributed Processing Laboratory of the Department of Applied Informatics, University of Macedonia, Thessaloniki, Greece World Federation on Soft Computing Artificial Intelligence-related Frequently Asked Questions Professional Organizations and Networks International Fuzzy Systems Association (IFSA) IFSA is a worldwide organization dedicated to the support and development of the theory of fuzzy sets and systems and related areas and their applications, publishes the International Journal of Fuzzy Sets and Systems, holds International conferences, establishes chapters and sponsors other activities. Japan Society for Fuzzy Theory and Systems (SOFT) Established in 1989. SOFT has 1,670 individual members and 74 company members, publishes an official bimonthly journal and organizes fuzzy systems symposiums. There are 8 regional branches and 8 research groups in SOFT. Berkeley Initiative in Soft Computing (BISC) BISC Program is the world-leading center for basic and applied research in soft computing. The principal constituents of soft computing (SC) are fuzzy logic (FL), neural network theory (NN) and probabilistic reasoning (PR), with the latter subsuming belief networks, evolutionary computing including DNA computing, chaos theory and parts of learning theory. North American Fuzzy Information Processing Society (NAFIPS) As the premier fuzzy society in North America established in 1981, our purpose is to help guide and encourage the development of fuzzy sets and related technologies for the benefit of mankind. Please mail questions/comments to the NAFIPS president (president@nafips.org) or to the NAFIPS web site maintainer (webmaster@nafips.org). Spanish Association of Fuzzy Logic and Technologies Promotes and disseminates the methods, techniques and developments of Fuzzy Logic and Technologies; Establish relations with other national or international Associations with similar aims; Organizes seminars and round tables on Fuzzy Logic and Technologies. Fuzzy Research Groups in Spain. The European Society for Fuzzy Logic and Technology (EUSFLAT) Established in 1998. The main goal of EUSFLAT are to represent the European fuzzy community of IFSA. To become a member of EUSFLAT please fill in the registration form. Hungarian Fuzzy Society Established in 1998. Honorary president: Tibor VÃ ¡mos. President: Imre Rudas. EUROFUSE Working Group on Fuzzy Sets of EURO Established in 1975. The purpose of EUROFUSE is to communicate and promote the knowledge of the theory of fuzzy sets and related areas and their applications. Telecommunication :: essays research papers Fuzzy Sets and Systems Lotfi A. Zadeh, The founder of fuzzy logic comp.ai.fuzzy New fuzzy archive by thread. Fuzzy Logic Tools and Companies. General sources of fuzzy information. Maintained by Bob John. Conferences and Workshops on Fuzzy Systems: 1990-2001 From the Parallel and Distributed Processing Laboratory of the Department of Applied Informatics, University of Macedonia, Thessaloniki, Greece World Federation on Soft Computing Artificial Intelligence-related Frequently Asked Questions Professional Organizations and Networks International Fuzzy Systems Association (IFSA) IFSA is a worldwide organization dedicated to the support and development of the theory of fuzzy sets and systems and related areas and their applications, publishes the International Journal of Fuzzy Sets and Systems, holds International conferences, establishes chapters and sponsors other activities. Japan Society for Fuzzy Theory and Systems (SOFT) Established in 1989. SOFT has 1,670 individual members and 74 company members, publishes an official bimonthly journal and organizes fuzzy systems symposiums. There are 8 regional branches and 8 research groups in SOFT. Berkeley Initiative in Soft Computing (BISC) BISC Program is the world-leading center for basic and applied research in soft computing. The principal constituents of soft computing (SC) are fuzzy logic (FL), neural network theory (NN) and probabilistic reasoning (PR), with the latter subsuming belief networks, evolutionary computing including DNA computing, chaos theory and parts of learning theory. North American Fuzzy Information Processing Society (NAFIPS) As the premier fuzzy society in North America established in 1981, our purpose is to help guide and encourage the development of fuzzy sets and related technologies for the benefit of mankind. Please mail questions/comments to the NAFIPS president (president@nafips.org) or to the NAFIPS web site maintainer (webmaster@nafips.org). Spanish Association of Fuzzy Logic and Technologies Promotes and disseminates the methods, techniques and developments of Fuzzy Logic and Technologies; Establish relations with other national or international Associations with similar aims; Organizes seminars and round tables on Fuzzy Logic and Technologies. Fuzzy Research Groups in Spain. The European Society for Fuzzy Logic and Technology (EUSFLAT) Established in 1998. The main goal of EUSFLAT are to represent the European fuzzy community of IFSA. To become a member of EUSFLAT please fill in the registration form. Hungarian Fuzzy Society Established in 1998. Honorary president: Tibor VÃ ¡mos. President: Imre Rudas. EUROFUSE Working Group on Fuzzy Sets of EURO Established in 1975. The purpose of EUROFUSE is to communicate and promote the knowledge of the theory of fuzzy sets and related areas and their applications.

Human sexuality Essay

Psychology illustrates love as a cognitive and social phenomenon of feeling of intimacy. According to Robert Sternberg devised a triangular theory love and claimed that love has three constituents’ commitment, intimacy and passion. Intimacy is a form through which two individuals share self-assurances and various aspects of their personal lives and is normally portrayed in friendships and romantic love affairs. Commitment is the expectation that the love will be enduring. Passionate love is shown through infatuation and sexual attraction together with romantic love. All forms of love differ with regard to passion, commitment and intimacy. Psychology holds that in love there is attachment, bonds, ties and affinity. Biological representation of love perceives love as a mammalian drive similar to thirst. Biologists view love as influenced by hormones like oxytocin, pheromones and neutrophins and the thoughts and behavior of individuals regarding love. The conservative perception in bilgy regarding love n that there are two major drives in love attachment and sexual attraction. Attachment between grown-up is assumed t work on the same principles that make an infant to get attached to the mother. Lust is the early passionate seal desire which encourages mating and entails increased release of hormones such as estrogen and testosterone. Attraction is the more personalized and romantic desire to a particular for mating that develops through lust as a commitment to a person mate forms. Present neural studies have shown that when individuals fall in love, the brain constantly discharges a particular set of chemicals such as dopamine, serotonin, pheromones, and norepinephrine that work in the same way as amphetamines. This stimulates the brain enjoyment center resulting to side effects which include; lack of sleep, increased heart rate, and loss of appetite and intense feeling of anticipation. Since last and attraction are only temporary attachment is the next stage that endorses the relationship to last longer based on commitments to marriage and child bearing. Attachment is associated with high proportion production of oxytocin and vasopressin. There are also high levels of nerve growth factor when individuals fall in love. Christian understanding regarding love is that love originates from God. Christian’s theologians perceive God as the ultimate source of love which is reflected in human beings and their own loving associations. Two connotations of love in Christian faith are agape love which defines selfless, humane, charitable and unconditional love. It is this love that was demonstrated in parental love, and viewed in creating the world, it trough this love God demonstrates his love for humankind and is the same love which Christian desire for one another. Phileo is the human love to something wonderful also known as brotherly love. Christians consider that people should Love God will all their heart, mind, and strength and love their neighbor as they love themselves as the greatest commandment.

Effective communication and interpersonal interaction in health and social care Essays

Effective communication and interpersonal interaction in health and social care Essays Effective communication and interpersonal interaction in health and social care Paper Effective communication and interpersonal interaction in health and social care Paper In this assessment I am going to demonstrate an understanding of effective communication and interpersonal interaction in health and social care. I am also going to talk about the types of communication i.e. formal and informal and also what is good or bad communication. One-to-one communication When starting a conversation with someone you have never met before, you should first try to start a positive atmosphere with the right kind of feeling. It is also very important to create a positive emotional atmosphere so that the person can feel comfortable with you from the start so you can discuss complicated issues or give information. For example when I was working in the nursery I had to talk to the child that was crying because they didn’t want to leave they parents so I had a one to one conversation with him and I made sure that the child knew that I was happy with him and wanted him to come play with me and to stop crying by my facial expression and body language. I asked him a lot of open questions like ‘What did you do at the weekend? and How was you Christmas? He was talking back. He felt relaxed and happy which made him forget about his parents not being around. He was happy to speak to me and he felt like he was not alone. How a conversation could go Greeting or a warm up Conversation or information exchange Farewells or winding-down When you have got someone talking and relaxed you have created a good feeling. You can now start to talk about anything with them. Sometimes you can even start a personal conversation asking how their health and family are and talk about any problems they are going through. When the conversation is coming to a end you would want the person to want to talk to you again so you have to leave with the right kind of emotions. You could end it with a phrase like ‘see you soon’ which shows them that you enjoyed their company and would like to talk to them again and to also show that you value them. Group communication Group communication only works when everyone is involved. Some people are open but on the other hand some people are quiet and don’t like to talk so they feel threatened if their have to speak within a formal group of people so there might stay quiet because they are worried about people reactions, I was working in a youth club and I had to get the children talking about an activity the club wanted to do with them. It’s very important that everyone in the group feels included because that will bring the right atmosphere and my job was to hear what they wanted to do. The youths in the group often use humour or other friendly ways of behaving to create the right group feeling, this will encourages them to talk and get involved. Creating the right atmosphere involves ‘maintaining’ the group so this aspect of group communication is often called group maintenance. Group leader There are different type of groups sometimes you need a leader and other times you don’t, but the groups with the leader turn out to be more successful than those with out a leader. In meetings or classroom discussions you would find a leader or a chairman for example in the youth meeting I took with the youths I was the leader and because the discussion had a leader it was successful everyone new I was the leader as well so when I said you talk there talk and I made sure there was no trouble makers there. When talking or arguing with your friends you often don’t have a leader that’s why it’s often loud and get out of control. Having a leader is very useful because the leader can encourage people to say what they have to say and for people to speak one at a time. The leading also often encourages people to focus on a particular task within a group. See of signs and symbols In a working environment signs and symbols are everywhere because its one of the best way of communicating without saying anything instead putting a picture where everyone can see it. I am going to be talking about how effective signs and symbols are in a care setting environment. People from backgrounds ages and even race if you put a sign in front of them there would be able to tell you what the sign says. When I was working in a nursery there was a child who could not speak English so we had to teach her using signs and symbols. When we wanted to talk to her we used sign language and she could understand everything we were trying to say. In the nursery I was working in there was lots of signs everywhere because children like colours, signs and symbols these are normally in lots of different colours. There could be signs or a symbol for every word in for example This sign mean wash your hands after using the toilet. Sign language is used a lot even in a nursery because Written communication Written communication is the best way of remembering what you have been told for example when I started my work placement I was given an introduction package showing me where everything was and what the nursery was all about. I still use it even through I am working there. Written communication allows you to keep information for as long as you want. When we had staff meeting we would have a sheet that tell as what the meeting is about before the meeting start and the order the meeting is going to go. When something is written its also easier to understand when someone is saying it because you can read it as much times as you want where us if someone is saying it and you miss what there said you would have to ask to say it again and if you keep asking then the person will be angry with you. In class when we are set work the teacher will tell us to write down or take notes on what he is saying so that when we are doing it alone we would know what to write and how to do it. In the nursery I was working in I had to do an activity with the children so I done a written activity where there are going to learn how to write and spell there names it was very successful because there got to take it home and learn it even more and now there all know how to spell there names and write it. Language (first language, dialect, slang, jargon) When it comes to language and communication it goes to ways because sometimes when you want to communicate with someone you have to speak in a language where there can understand you. Because different localities, ethnic groups and cultures all have their own way of communicating with each other and if you’re not from that group you would not be able to understand what there saying. The fact that you can’t understand what there saying some people are threatened or exclude by the kind of language they encounter in these speech communities however just using formal language will not solve this problem for example jargon is when complicated words are been used because the person and the phone is not going to understand so the communication with you and the person will be broken. People from different geographical areas also use different ways of speaking to each other for example there are words that is used in south east London that are not used in north London for example strap in south means gun straly in north also means gun this is called slang. Slang is non-standard words that are understood by other members of a speech community but which cannot usually be found in a dictionary. When I was working in my nursery I child came from France and not speak a word of English so it was hard to communicate with her so we had to teach her English using her language and mixing it will English so that she can learn. There was another case where a child has an older brother and the older brother speaks slang and the child picked it up and could understand so when I speak to the child I would use slang and the child could understand me more than any other teacher. It is very hard to communicate with someone if don’t speak there language because you would have to keep repeating yourself. According to the author and psychologist Steven Pinker (1994) estimated that there maybe about 600 languages in the world that are spoken by more than 100,000 people he also believe that there are many more minority languages. Some people grow up in multilingual communities where they learn several languages from birth. Where us children in the UK have grown up to only use one language to think and communicate with which is English. The people who learn second language later on in life often find that they cannot communicate their thoughts as effectively as they might have done using their first language. The first language that people have learned to think in usually becomes their preferred language. Non-verbal communication (posture, facial expression, touch, silence, proximity, reflective listening) From the first time you meet someone you usually be able to tell how there are feeling for example if there angry, tried, happy, sad and even frightened even if there haven’t said anything. You can usually guess what a person feels by studying their non-verbal communication. Non-verbal means with out word. We send this message using our eyes, the tone of our voice, facial expression, our hands and arms, gestures with our hands and arms, the hands and arm the angle of our head, and the way we sit To tell people what you‘re thinking of or how you are feeling. When I was working in nursery from the first moment I walked in the room where the kids was I new their characters just my the way their was sitting to listen to the story for example some children were next to the teacher listen to teacher does was the children I thought are good students and a child was trying to talk to the other and he said no. So from that moment I could just see who troubles are and who are not. From the moment I walked in I new the children that was happy to see and the ones that are not just by their facial expression and when I said hi the voice of their voice in the reply. I was talking to a member of staff and this child came up to me and put his hands out and I picked him up I didn’t even have to say anything for the child he just felt happy with me. The use of British sign language The British sign language is used in the UK and it’s the first preferred language of some deaf people. The language involves movement of the hands, body, face and head. Thousands of people who aren’t deaf also use British sign language for example if a person is angry and someone is asking them a question they might answer with a head nod. As hearing relatives of deaf people, sign language interpreters or as a result of other contact with the British deaf community Use of sign Its not only people who have a disability .i.e. deaf or blind use signs and signed languages to communicate as many people who have perfect hearing frequently use non-verbal communication techniques when your out socializing with friends and even out home. We all use sign language in fact it is probably used more often than we realise as sometime you are unaware that you are using forms of sign language to communicate. Variation between cultures Culture variations can have a big effect on the way people communicate non-verbally. For example actions that are not seen as offensive in your home country may be seen very offended to foreign countries. That’s why communication with people from different cultures is especially challenging. Cultures provide people with different ways of thinking, seeing things, hearing, and interpreting the world.

Histoty of the RMS Olympic

Histoty of the RMS Olympic RMS Olympic was the longest lived of the Olympic Class liners White Star Line constructed to compete with Cunard's Lusitania and Mauretania.While her sister ships Titanic and Britannic went to the bottom, Olympic prospered and even served her country in war time as a troopship, earning the nickname "Old Reliable" after proving herself unsinkable time after time.As is the case with ocean liners who manage to stay afloat, Olympic's sailing days eventually ended and she was sold off for scrap metal. Her memory lives on however in the pages of this site.RMS Olympic, in the course of her nearly 25 years at sea, earned the name "Old Reliable". Besides being cherished by her passengers and crew alike, Olympic proved herself time and time again to be a ship that could not be stopped or sunk. When World War I broke out in August 1914, Olympic remained in commercial service.RMS Olympic passes Nantucket Lightship 117 in earl...She once rescued the crew of a British battleship off the coast of I reland. The warship had struck a mine and was sinking fast.In September of 1915, the Royal Navy requisitioned her as a troop ship. She was painted in various colors and geometric shapes and refitted to carry more lifeboats and thousands of troops in a crossing. During her war service she survived four submarine attacks, turning one of them into an attack of her own as she turned on the enemy sub and rammed it. Although a glancing blow, with more than 46,000 tons of steel behind it, it was more than enough to sink the German submarine, forcing its crew to abandon ship. All told, Olympic transported more than 120,000 civilian and military personnel across the Atlantic and was, like so many liners drafted for war duty, instrumental in bringing the war to...

The Medici Collection and The Louvre Essay Example | Topics and Well Written Essays - 3000 words

The Medici Collection and The Louvre - Essay Example al languages have essentially three component parts, one of which is the direct use of signs and symbols in the form of objects and space while the other two, non-verbal communication such as gestures and body language and verbal communication such as speech and writing, can also be preserved somewhat in the objects that are left behind and can help in determining the culture from which the object originated. Because objects share a role in the interrelated social communication modes of a particular society, the interpretation of these objects may differ from one society to the next or even one time period to the next. The way in which it is interpreted can not only provide significant contextual clues to the society from which it was produced, but can also reflect the understanding of the society attempting to place the object within its correct contextual space. In addition, that exact same object, for example a specific vase, may take on different contextual meanings as it passes through time, originally used as a container for liquid, later taking on the ashes of a dearly departed relative and finally symbolizing perhaps a golden age in the progression of a nation. â€Å"[An object] can never convey one single message, uncorrected, unambiguous and unqualified. Different social perceptions, needs and changing attitudes will see to that.†2 The nature of the collection and the context in which the museum or collection places its artwork for display to the public can thus have a significant effect upon the interpretation and perceived value of the work. These ideas can be seen when comparing the extensive collection of a museum such as the Louvre to the eclectic and less organized Medici Collection. Until relatively recently, the concept of art museums in which great works of artistic merit were held in the name of the public trust was a foreign idea. However, the concept of collecting art as a means of personal gratification, cultural enrichment and

Explain what you understand by the term Securitisation and consider Essay

Explain what you understand by the term Securitisation and consider why a bank might choose to securitise some of its loans - Essay Example It ends up losing some cash flows or assets in return for the cash. This debt also not reflected in the bane sheet of the ultimate bower. Therefore, securitisation can be viewed as a method of disposing off a cash flows stream. Besides the impact on the borrower, securitisation benefits investors as well. It increases the variety of choices of investments available. The securities that are asset-backed by way of securitisation can be easily analysed since investors need only to undertake an evaluation of cash flows from a very small assets pool. This saves them from having to evaluate the entire complex business. The most commonly securitised assets are loans of a single kind or another type which when pooled becomes an investment of low risk. Also, it means that in the context of the issuer, it is often a borrowing way that’s very cheap. (Moneyterms.co.uk, 2009). This is a study set out to discuss this issue of securitisation and to this there will be a vivid answering of the questions â€Å"what is securitisation?† and â€Å"why do banks choose to securitise some of their loans?† Securitisation is an expression that has become more common in usage and it’s usually used the numerous mechanisms of transferring risks between the parties involved. It usually includes the description of the scale or disposal of risk assets in an absolute manner or the synthetic transfer of particular risk aspects. It is used in several contexts and among various parties who indulge in contracts. More comprehensively, it’s defined as the process via which receivables, loans or other relevant assets are put together. The cash flows that go with the assets and also the economic values deployed to aid payments of the securities related. The related securities are issued in both private and public markets by issuers or on their behalf, which use the process of securitisation to

Stratification by Gender and Agege Essay Example | Topics and Well Written Essays - 1000 words

Stratification by Gender and Agege - Essay Example To make this discipline work, theoretical frameworks in the form of theories are used to explain and analyze social actions, structures and various social processes. These theories aid in organizing social research. It is imperative to realize the significance of these theories not only to develop a positive attitude towards life and society but also to modulate the situation so as to add meaning to it in a cognitive and overall holistic development (Schaefer, R, 5th Ed). Sociological theories explaining stratification by gender and age are based on theoretical assumptions encompassing positivism, materialism, idealism, determinism, individualism and free will (Schaefer, R, 5th Ed). They provide an attitude towards critical thinking that includes rationality, logic, objectivity and knowledge (Schaefer, R, 5th Ed). It is an essential tool used by scholars to analyze the society and therefore these are interdisciplinary, drawing ideas from and contributing to various disciplines of human endeavor (Stark, 2007). Gender responsibilities require proper behavior, attitudes and activities of both males and females in the society. The social theories defining stratification by gender signify women as an oppressed majority group and must be feminine, soft, emotional, sweet and submissive while boys or males must be masculine, aggressive in temperament, tough, daring and dominant (Schaefer, R, 5th Ed). ... Women perform the roles of being expressive and emotionally supportive while men take the role of being instrumental and practical (Schaefer, R, 5th Ed). According to the conflict response of the sociological theory there is no parallel power relationship between men and women. Women are always considered as the weaker gender and men have a dominant position over women. This difference is due to suppression of women by men (Schaefer, R, 5th Ed). According to the feminist perspective, in capitalist societies, women's subordination in injustice and exploitation is prevalent. This has gained pace with the rise in private property during industrialization (Schaefer, R, 5th Ed). The dominance of men is also seen in the interaction theory which states that men are more likely to change topics of conversation or rather ignore topics chosen by women. The theory further states that if the idea is given by a women then it doesn't gain much appreciation rather women are always interrupted (Schaefer, R, 5th Ed). The stratification by gender also brings focus on the ideology of sexism which states that one sex (male) is superior to other (female). It also encompass discrimination and male prejudice leading to sexual harassment. Sexual harassment also involves work benefits, favors, touching, lewd comments and thereby creating hostile environment (Schaefer, R, 5th Ed). This stratification is prevalent all over the world and therefore women remain in second-class position in major part of the world especially in the developing countries and are exploited for labor (Schaefer, R, 5th Ed). The gender stratification is also prevalent in developed nations like US but still is underrepresented in occupations defined as "men's jobs" which keep

Ethnicity and Culture in Disease Prevention Essay Example for Free

Ethnicity and Culture in Disease Prevention Essay Importance of addressing race, ethnicity, and culture when developing programs for prevention of disease Name: Subject: Instructor: Date: The campaigns against diseases have a number of times botched as a result of non-recognition of environmental, biological and behavioral factors as major determinants as of individual health. In public health, the three terms (ethnicity, race and culture) are often used interchangeably. The implementation of disease prevention programs in a community requires full knowledge of the health status of its members. With this regard, racial and ethnical categories often define populations in a manner that is meaningful to their health status (Nnakwe, 2009, p. 337). The concept of race, ethnicity and culture plays a significant role in understand human behavior. Thus it is rational to incorporate the aspect of race, culture and ethnicity a when designing disease prevention programs in communities. For instance, designing a disease prevention program require the use of social ecological framework. The framework focuses on interactions between an individual’s physical, cultural and social setting and thus it may be the only necessary move in a fight against disease in an ethnic group. In this case, the knowledge about a disease should not only be transferred but also needs to be cultivated thought peer support, supportive social norms and cultural values. Consider a case where the government decides to put up a facility for provision of free condoms at the core of a very conservative community as part of a program for prevention of HIV/Aids. Will such a program receive support from the community? Of course not as this will be taken as a violation of the community’s cultural values since it may lead to moral decay among its members. Therefore cultural values of a community must be addressed and prevention programs should be aligned with those values. Health care providers need to train on cultural competency in order to understand barriers and influence of culture and society on health behaviors as well as the use of behavior change tools that are culturally sensitive. Ethnicity /race may also affect, directly or indirectly, the success of a disease prevention program in a community, e. . cultural beliefs about HV/Aids (Edelman Mandle 2005, p. 48). For example the risk of obesity starts at a person’s prenatal period. Race/ethnicity may therefore affect the prevention of obesity since it influence the timing of pregnancy, number of pregnancies together with intervals between pregnancies. In conclusion, the public health approach towards prevention of disease must into consideration culture, race and ethnicity within a social ecological framework as an effort towards sustaining a disease free society.

Qualitative aspect of drug action

Qualitative aspect of drug action Qualitative aspect of drug action Schild plot Schild plot: Schild plot is defined as pharmacological method of receptor classification. By using schild plot dose-effect curve for an agonist is determined in the presence of various concentrations of a competitive antagonist for its receptor in the presence of agonist i.e. equilibrium dissociation constant is calculated. The experiment is carried out for series of dose ratios for a given effect. For example the ratio of the dose of agonist (A) to produce a specific effect (e.g.,half maximal effect) in the presence of the antagonist (B) to the dose required in the absence of the antagonist (A) is calculated. This is determined for several doses of antagonist and then log ((A/A) -1) versus the negative log B is plotted. If the regression of log ((A/A) -1) on -log B is linear with a slope of -1, then this indicates that the antagonism is competitive and by definition the agonist and antagonist act at the same recognition sites. If the slope of the regression is not -1, then by defini tion the antagonist is not competitive or some other condition is in effect. This might include multiple binding sites or pharmacokinetic interactions. Agonist: Agonist is a drug which has both affinity and efficacy. Antagonist: Antagonist is a drug which has affinity and zero efficacy. Affinity:Affinity is a property of a drug; it measures how tight a drug binds to a receptor. To bind to a receptor a functional group of the drug should bind to the complementary receptor. The binding capacity of the drug defines the action of the drug. Efficacy: Efficacy of a drug can be defined as ability of drug which activates the receptor to produce desired effect after binding. Affinity and efficacy are explained in the equation as: K+1 ÃŽ ± A + R AR* Response K-1 ÃŽ ² K+1 B + R BR No Response K-1 Where A is agonist, B is antagonist, K+1 is association rate constant for binding, K-1is dissociation rate constant for binding ÃŽ ±- Association rate constant for activation ÃŽ ²- Dissociation rate constant for activation By using law of mass action affinity is explained as B + R BR Drug free receptor drug-receptor complex At equilibrium KB = [R] [B] KB = Equilibrium dissociation constant [BR] Hill-Langmuir equation: this equation explains drug occupancy [RT] = [R] + [BR] If [RT] = Total number of receptors then by substituting this in law of mass action equation [RB] = [B] [RT] KB + [B] By this equation it is determined that drug occupancy (affinity) depends on drug concentration and equilibrium dissociation constant. Equilibrium dissosciation constant: EQUILIBRIUM DISSOCIATION CONSTANT (Kd) : It is the characteristic property of the drug and the receptors. It is defined as the concentration of the drug required to occupy 50 % of the receptors. The higher the affinity of the drug for the receptors lower is the Kd value. Mathematically Kd is k2/k1 where k2 is the rate of dissociation of the drug from the receptor and k1 is the rate of association of the drug for the receptor. Receptor (R) and Drug (D) interact in a reversible manner to form a drug-receptor (RD) complex. Where R = Receptor D = Drug (L for ligand is sometimes used in these equations) k1 = the association rate constant and has the units of M-1min-1 k2 = the dissociation rate constant and has the units of min-1. k2 is sometimes written as k-1. If an agonist binds to the receptor, then the interaction of the agonist (D) and the receptor (R) results in a conformational change in the receptor leading to a response. If an antagonist binds to the receptor, then the interaction of antagonist (D) and receptor (R) does not result in the appropriate conformation change in the receptor and a response does not occur. For drugs that follow the law of simple mass action the rate of formation of the complex can be defined by the following equation d[RD]/dt refers to the change in the concentration of [RD] with time (t). Note: the square brackets refer to concentration. This equation indicates that the rate at which the drug receptor complex (RD) is formed is proportional to the concentration of both free receptor (R) and free drug (D). The proportionality constant is k1. The rate of dissociation can be defined by the following equation -d[RD]/dt is the decrease in drug-receptor complex with time This equation indicates that the rate at which the drug-receptor complex (RD) dissociates back to free drug and free receptor is proportional to the concentration of the drug receptor complex. The proportionality constant is k2. When the drug and the receptor are initially mixed together, the amount of drug-receptor complex formed will exceed the dissociation of the drug-receptor complex. If the reaction is allowed to go for a long enough, the amount of drug-receptor complex formed per unit time will be equal to the number of dissociations of drug-receptor complex per unit of time, and the system will be at equilibrium. That is equilibrium has occurred. Equilibrium can be defined as or k1[R][D] = k2[RD] This equation can be rearranged to give Kd is the dissociation equilibrium constant. Kd has units of concentration as shown in the following equation. Simple competitive antagonism: simple competitive antagonism is the most important type of the antagonism. In this type of antagonism the antagonist will compete with available agonist for same receptor site. Sufficient antagonist will displace agonist resulting in lower frequency of receptor activation. Presence of antagonist shifts agonist log dose response curve to right. A schild plot for a competitive antagonist will have a slope equal to 1 and the X-intercept and Y-intercept will each equal thedissociation constantof the antagonist. This can be explained in equation as: Occupancy for agonist [RA] = [A] OR [A]/ KA [RT] KA+ [A] [A]/ KA +1 In presence of competitive antagonist (B) [RA] = [A]/ KA [RT] [A]/ KA + [B]/ KB + 1 Occupancy reduced according to [B] and KB To obtain same occupancy, must increase [A] to [A`] r = [A] / [A] = [B] / [B] Schild equation: r = [B] / KB +1 Where r depends on [B] and KB Applying log on both sides log (r-1) = log[B] log KB Aim: The main aim of the experiment is to measure the equilibrium dissociation constant (KB) for atropine at acetylcholine muscuranic receptors and to determine the drug receptor interactions. Objectives The main objectives of the experiment are as follows Ø To measure the equilibrium dissociation constant for atropine at acetylcholine muscuranic receptors Ø To demonstrate the reversible competitive antagonism of atropine at acetylcholine muscuranic receptors Ø To determine the equilibrium dissociation constant (KB) for atropine at acetylcholine muscuranic receptors by using schild plot. MethodIsolation and mounting of Guinea-pig ileum in organ bath Guinea-pig was first sacrificed and then the ileum was collected and transferred into physiological salt solution maintained at 370C. The food particles present in the ileum was expelled out through running Krebs solution through the lumen. Then tissue was tied with a thread at both the ends where one was tied to the mounting hook and the other was attached to the transducer. 1) Preparation of serial dilutions of drug The drugs used in the experiment were acetylcholine (Ach) and atropine. To determine the simple competitive antagonism of atropine at Ach muscuranic receptors serial dilutions of Ach were carried out. Ach was given as 110-2M and from the above concentration of the drug the following concentrations were prepared to the organ bath concentration such as 110-6M, 310-6M, 110-7M, 310-7M, 110-8M, 310-8M, 110-9M and 310-9M Ach. Then atropine was diluted to 110-8M (organ bath) from the given 110-2M concentration. 2) Determination of Organ bath concentration The volume of physiological salt solution (pss) was 20 ml, and each time the volume of drug introduced into organ bath was 20Â µl.Therefore if 20Â µl of 110-2M drug was introduced into the organ bath then it gives 110-5M organ bath concentration. Mathematical calculation of organ bath concentration: In organ bath we have 20ml of pss which is equal to 20103 Â µl of pss, if 20 Â µl of 110-2 M Ach was introduced then the organ bath concentration 20Â µl→XM 20ml→10-2M = 20 Â µl x 10-2 M 20x 103 Â µl = 110-5M (organ bath concentration). The isolated guinea- pig ileum was mounted onto the organ bath and set up for recording isometric tension of the tissue using chart software in a Mac book. Step-1 Calibration of the experimental apparatus: The chart 5 software was calibrated and the sampling rate was adjusted to 10 samples per second with a maximum input voltage to 10 mV. The baseline was set to zero and then trace was started from the baseline zero then the force transducer was calibrated by placing 1 gram weight and after the calibration the trace produced was stopped for the moment to convert the units of tension into grams by selecting the trace produced previously. Step-2 Sensitisation of preparation: To check the viability of the tissue a response of suitable height was obtained by adding a little high concentration of the drug. Here in the experiment an appreciable recording was noted at 110-7M Ach. Step-3 The time cycle followed to construct a concentration- response curve was 0 seconds to add the drug concentrations 30 seconds to empty the organ bath and refill with fresh physiological salt solution 180 seconds next drug concentration was added to the organ bath. Concentration Response Curve: By making use of the above drug concentrations a concentration response curve was constructed according to the provided time cycle. 1) 20 Â µl of 110-9M Ach was added into the organ bath at zero seconds at is allowed to stand for 30 seconds, then after 30 seconds the organ bath was emptied and refilled with pss. Pss was allowed to stand for 180 seconds. During the wash period if the peak does not return to the base then it was washed twice or thrice to make sure that all the drug dissociates from the receptors before the next addition of the other drug concentration. Each concentration was repeated twice or thrice until the two consecutive responses were reported with the same peak height. 2) By following the procedure and time cycle, the concentration response curve was constructed with different concentrations of acetyl choline such as 110-9M,310-9M, 110-8M, 310-8M, 110-7M, 310-7M, 110-6M and 310-6M Ach (organ bath concentration). Step-4 Equilibration of Acetylcholine receptors with acetylcholine After step-2 the preparation was washed several times until the peak returned to the base line. Then atropine (110-8M organ bath concentration) was added to the preparation and then set aside for 40 minutes to allow atropine to equilibrate with acetylcholine muscuranic receptors. Step-5 Concentration response curve in the presence of atropine The concentration response curve with acetylcholine was repeated again in the presence of atropine by following the time cycle and procedure, which was same as same step 2.Therefore in step 3 with each addition of acetylcholine concentration atropine was added simultaneously. Step-6 Analysis: i) The graph pad prism in the Mac book was used to plot concentration response curves in the absence and presence of atropine. Log concentration (acetylcholine) Vs response in grams ii) From the above plot EC 50 values of acetylcholine in the presence and absence of atropine were obtained. Then the distance between the two curves control and response for the atropine presence was denoted by ‘r, where ‘r was called as shift. iii) The shift was calculated mathematically as r= EC 50 of response in the presence of atropine EC 50 of Ach in the absence of atropine iv) From the value of the shift, schild plot was plotted as log concentration of atropine presence against log(r-1). v) From the schild plot the dissociation constant KB for atropine at acetylcholine muscuranic receptors was determined. Results: As explained above in the procedure serial dilutions of acetylcholine was added to the organ bath, where Ach has produced concentration dependent contractions of the guinea pig ileum as shown in the fig 1. As shown in 1 the serial dilutions of acetylcholine are added into the organ bath from 110-7M to 310-6M Ach. Here in the trace it was clearly shown that contractions produced by the acetylcholine have been increased with respect to the concentrations. In step-2 the preparation was washed and added with 110-8M atropine and set aside for 40 minutes to equilibrate the acetylcholine receptors. In the trace it is clearly shown that, the contractions produced by serial dilutions of Ach from 110-8M to 310-4M in the presence of 110-8M atropine. When Trace 1 and Trace 2 are compared it is evident that the contractions produced by Ach alone (trace 1) were greater than the contractions produced Ach in the presence of atropine (trace 2) which proves the simple competitive antagonism by atropine at muscuranic receptors. A graph is plotted to the log concentration response curve produced by Ach alone against Ach in the presence of atropine. (graph is attatched to the report) From the graph it is known that with the increase in the concentration of Ach, response have been increased when compared to Ach in the presence of atropine and also there is a shift towards right which shows the simple competitive antagonism produced by atropine. From the results produced by Ach alone against Ach in the presence of atropine the fractional difference which is called as shift can be obtained as follows Mathematical Calculation shift ‘r = EC50 of response after atropine (or) in the presence of atropine EC50 of control (or) Ach in the absence of atropine = 2.5110-6 = 8.36 3.0 x10-7 r-1 =8.36 -1=7.36 log(r-1)=log (7.36) =0.86 Partial dissociation constant (PKB) or PA2 is measured to confirm the simple competitive antagonism, where pKB values play an important role in classifying receptors. Therefore PKB =log(r-1) -log [atropine] =0.86 -log (110-8) =0.86 (-8) =0.86+ 8 =8.86 From the above results log EC50 values for control (Ach alone) and Ach in the presence of atropine were given as 3.0e-007 and 2.51e-006 respectively. This shows the molar concentration of Ach which produces 50% of the maximal possible response is higher than the molar concentration response produced by Ach in the presence of atropine. If the antagonist is competitive, the dose ratio equals one plus the ratio of the concentration of antagonist divided by its Kd for the receptor. (The dissociation constant of the antagonist is sometimes called Kb and sometimes called Kd) MathType Equation A simple rearrangement gives: MathType Equation Here we have plotted a graph with log (antagonist) on the X-axis and log (dose ratio -1) on the Y-axis. If the antagonist has shown simple competitive antagonism then the slope should be 1.0, X-intercept and Y-intercept values should be both equal the Kd of the antagonist obtained. If the agonist and antagonist are competitive, the Schild plot will have a slope of 1.0 and the X intercept will equal the logarithm of the Kd of the antagonist. If the X-axis of a Schild plot is plotted as log(molar), then minus one times the intercept is called the pA2 (p for logarithm, like pH; A for antagonist; 2 for the dose ratio when the concentration of antagonist equals the pA2). The pA2 (derived from functional experiments) will equal the Kd from binding experiments if antagonist and agonist compete for binding to a single class of receptor sites. From 5 and 6 it is evident that no concentrations of atropine have showed competitive antagonism perfectly. Therefore from the above results it is known that the concentrations of atropine has not shown simple competitive antagonism fairly. Discussion: Reversible competitive antagonism: The binding of drug to a receptor is fully reversible which produces a parallel shift of the dose response curve to the right in the presence of an antagonist. The mechanism of action of acetylcholine at muscuranic receptors: In various gastrointestinal smooth muscles, acetylcholine and its derivatives produce contractions by activating muscuranic receptors. It is generally assumed that the M3 muscuranic receptor plays a key role in mediating this activity. The M3 receptor is coupled preferentially to Gq-type G proteins, resulting in the activation of phospholipase C (PLC) and the formation of ionositiol trisphosphate (IP3) and diacylglycerol (DAG) which are likely to participate in muscuranic receptor-mediated smooth muscle contractions. IP3 causes Ca2+ release from intracellular store and can also mobilize Ca2+ secondarily through Ca2+-sensitive or store-dependent mechanisms. DAG, via activation of protein kinase C, phosphorylates various proteins and can directly activate non selective cationic channels. From the above results the value of shift obtained was 0.378 which denotes the simple competitive antagonism produced by the concentration of atropine used (110-8 M).From the value of shift the pKB value was calculated as 8.4.If atropine has shown simple competitive antagonism then the value of pKB should be equal to 1-X intercept. Therefore pKB=1-X intercept =1-(-8.86) =9.86 We got value of pKB as 8.86.Therefore pKB is not equal to 1-X intercept. Therefore the concentration of atropine (110-8M organ bath concentration) used by our group has not shown simple competitive antagonism effectively. The literature value of pKB is given as approximately 9 and we have obtained the value of pKB as 8.86 which does not fit with literature value. Therefore from the above observations and results i can conclude that a little more high concentration of atropine may serve to produce complete simple competitive antagonism by atropine at acetylcholine muscuranic receptors.